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KMID : 0380420010250020103
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Journal of Prventive Veterinary Medicine
2001 Volume.25 No. 2 p.103 ~ p.106
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Urinary and Blood Porphyrin Profiles as Biomarkers of Diazinon Exposure in Rats
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Abstract
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Urinary and blood porphyrin contents were measured in rats exposed to diazinon in order to examine the usefulness of porphyrin profiles as biomarkers of diazinon (organophosphorus insecticide) exposure. Rats were given diazinon(10, 30 and 90 mg/kg b.w) once per day for 5 weeks by gavage and thereafter were given distilled water for further 5weeks. Among the urinary porphyrins, coproporphyrin and uroporphyrin began to increase from the 3rd week of the administration of diazinon and the tendency of increment continued up to 5 weeks(coproporphyrin) or 3 weeks(uroporphyrin) after the withdrawal of diazinon exposure. Protoporphyrin content showed no significant change compared with that of control throughout the whole period of experiment. Of the blood porphyrins, protoporphyrin content of diazinon-treated group was higher than that of control group from the 5th week of exposure to the end of experiment. Uroporphyrin was not detected in the both of control and treatment group. Coproporphyrin level of the treatment group was not significantly differnt from that of control. The results suggest that urinary and blood porphyrin profiles may contribute as biomarkers for diagnosis of diazinon exposure.
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